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You can buy Orlistat (Xenical/Alli) as an over-the-counter alternative to Wegovy in the UK.

However, Orlistat is a very different type of weight-loss medication, and research suggests it’s not as effective as Wegovy in supporting weight loss.

What’s the difference between Orlistat and Wegovy?

Wegovy and Orlistat are weight-loss medications approved for use in the UK. However, they are different medications with distinct dosing schedules, costs, and mechanisms of action on the body.

Orlistat is a lipase inhibitor. Lipases are gut enzymes that break down fat from food, enabling the gut to transport fat into the body to be burnt for energy or stored in our fat cells for later use.

Orlistat blocks lipases, preventing some of the dietary fat from our meals from being digested. This leads to fewer calories being absorbed, which can support weight loss.

Orlistat is a prescription medication produced by two pharmaceutical companies in the UK:

  • GlaxoSmithKline: Alli, 60 mg and available over the counter (no prescription)
  • Roche: Xenical, 120 mg and available with a prescription

Wegovy is a weight-loss jab manufactured by Novo Nordisk. It’s a weekly weight-loss injection with semaglutide as the active ingredient.

Semaglutide is a that helps reduce hunger and appetite, allowing you to eat fewer calories, lose weight, and manage your blood sugar levels.

Wegovy is approved in the UK for individuals living with obesity to help them eat fewer calories and lose weight.

How much do Wegovy and Orlistat cost?

The over-the-counter version of Orlistat will cost around £18 a month, so it’s a very affordable medication.

In comparison, buying Wegovy and the injectable pens required for four weeks from Second Nature will cost £229 a month, rising to £299.

Should I try Orlistat or Wegovy for weight loss?

Orlistat is an affordable medication that is generally well-tolerated. However, it’s less effective than Wegovy. Wegovy is twice as effective as Orlistat for weight loss after one year.

So, if you’re looking for the most affordable weight-loss pill you can purchase over the counter, then Orlistat could be an option.

However, if you have a higher budget and are looking for the most effective weight-loss injection in the UK, semaglutide is a better choice.

Wegovy’s not a magic pill

Semaglutide is designed as an additional tool for weight management and, in most cases, shouldn’t be considered a lifelong medication.

Instead, it should be used to help you kickstart your weight loss and healthy journey while you commit to living a healthier lifestyle.

Ideally, we’d be able to lose weight without medication and lifestyle changes would be enough to support weight loss in the long term.

We’d generally recommend trying Second Nature’s before considering a weight-loss jab.

Changing your habits is the most sustainable way to achieve long-term weight loss, and it’s also less expensive.

At Second Nature, we’ve been trusted by the NHS since 2017 to support people with type 2 diabetes and obesity to lose weight, manage their blood sugar levels, and lead healthier lifestyles for the long term.

In 2022, the NHS in the BMJ that compared the weight loss outcomes of five providers in the National Diabetes Prevention Programme.

Second Nature was more than twice as effective at supporting weight loss than the other four providers.

However, if you’ve decided to try semaglutide (when it’s available) but need support in making positive changes to your lifestyle, Second Nature could be an option for you. But it’s worth noting that we have strict eligibility criteria.

Second Nature has been in medicine for more than 8 years and offers a wide range of FDA-approved weight-loss drugs.

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Common Ingredients

Milk, lactose free milk or lactose free dairy-free milk or milk almond milk, coconut milk, almond, soy, coconut, soybean and starchy vegetables, is the same ingredient as yoghurt but without the added sugar.

Features and Uses

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Side Effects

Common Side Effects: Gastrointestinal disorders (e.g. flatus personality, oily or fatty stools). Headache and insomnia

Serious Side Effects:Anorexia, constipation, weight gain, muscle cramps, weakness, numbness, tingling, burning eyes and mouth, blurred vision. Nausea, vomiting, stomach cramps, diarrhea. Diarrhea. Constipation. Dizziness, dry mouth, insomnia. Drowsiness, dry and itchy skin, feeling of being cold, weight loss, increased thirst, increased urination. Skin rash, itching, swelling of sensitive skin, hair loss, swelling of legs or ankles. Drowsiness, restlessness, muscle twitching, increased sweating, trouble sleeping. Confusion, confusion, difficulty speaking, trouble speaking, trouble speaking, trouble talking, trouble thinking, muscle twitching, trouble walking, tremors, muscle pain, numbness, tingling, skin rash, itching. Yellow skin (e.g. itch, itch, itch), unusual weakness, muscle pain, tingling or numbness, burning, weight gain, fast or uneven heartbeat, feeling faint or lightheaded. Back pain, muscle pain, pain in or around the face, skin rash, feeling dizzy, itching or burning in the chest, skin rash, feeling faint or lightheaded. Creatine kin may occur. Elevations of blood pressure, heart rate, fever, swollen glands, increased sweating, muscle weakness, muscle stiffness, confusion, weakness, tiredness, restlessness, fever, fatigue. Abnormal or unexpected vision or hearing. Loss of consciousness. Seizures. Tingling or pain in the throat, tongue, lips, hands or arms, difficulty speaking, trouble speaking, pain in the chest, feeling faint.

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Alli is a top weight-loss brand in Turkey,...View MoreAlli is a top weight-loss brand in Turkey, offering a range of effective products. With trusted reviews and a commitment to quality, Alli helps individuals achieve their weight-loss goals safely and efficiently.View LessRead More

Explore About Alli & Its Products

Alli is a brand of medication that is used for weight loss. It contains the active ingredient Orlistat, which blocks the absorption of fat in the body. Alli is sold over-the-counter and is meant to be used in combination with a low-fat, reduced-calorie diet and exercise program.

- Alli was launched in 2007 by GlaxoSmithKline.

- It was the first FDA-approved over-the-counter weight loss medication.

- In 2014, ownership of the brand was transferred to the British company Reckitt Benckiser.

- Alli is currently available in the United States, the United Kingdom, and Australia.

Brands Similar to Alli

Xenical is a prescription weight loss medication that also contains Orlistat as its active ingredient. It is marketed by Roche Pharmaceuticals and is available in many countries around the world.

PhenQ is a weight loss supplement that contains a blend of natural ingredients. It is marketed by a company called Wolfson Berg Limited and is available for purchase online.

Hydroxycut is a brand of weight loss supplements that are marketed by Iovate Health Sciences International. The brand offers a variety of products that contain different active ingredients, such as caffeine and green coffee extract.

Top Trending & High Rated Products of Alli

Alli Capsules

Alli Capsules are the brand's flagship product. Each capsule contains 60mg of Orlistat and is meant to be taken with meals that contain fat.

Common Questions Asked by Customers About Alli & Its Products

What is Alli used for?

Alli is used for weight loss. It works by blocking the absorption of fat in the body.

How do I take Alli?

Alli is meant to be taken with meals that contain fat. You should also follow a low-fat, reduced-calorie diet and exercise program while taking this medication.

Is Alli safe?

Alli is generally considered safe when used as directed. However, it can cause some side effects, such as diarrhea and abdominal pain.

How much weight can I expect to lose with Alli?

Studies have shown that people who take Alli in combination with a diet and exercise program can lose up to 5% of their body weight within six months.

Can I take Alli if I am pregnant or breastfeeding?

No, Alli is not recommended for use during pregnancy or breastfeeding.

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agyi Pharma UB PHY LABarrett LABbook Description

Dr. Yanmi Yanmi is an experienced weight loss physician with extensive clinical experience in the treatment of obesity and related health conditions. She has extensive experience managing the complex journey of obesity, aiming to ensure that she is well-versified in the care of patients with obesity, including their parents, healthcare professionals, and caregivers. Yanmi graduated from Yarbong University, with a B. A. in Pharmaceuticals with a focus in Pharmaceutical Medicine. She has published extensively in medical literature and is a frequent contributor to weight loss products and guides on medication management.

Is my refcessive with this drug good?

Yanmi's reflux is not uncommon.

The Orlistat industry is on a rollercoaster: It’s a juggernaut, with a market share of around 37% in its first three quarters. But it’s getting smaller. So, what’s behind that?

The Orlistat market is a global industry with several key factors, from its size to its overall growth rate:

  • The global demand for Orlistat is expected to rise, driven by growing demand for diet-friendly and weight-loss drugs.
  • The market for Orlistat is growing at a compound annual growth rate of 2.2% annually, while its market share is expected to grow to 6% from 5% in the first quarter of 2014.
  • The pharmaceutical industry is seeing a big shift in its pharmaceutical offerings: Research and Development (R& D) is increasing at a faster rate, while the consumer healthcare sector is on the rise. For instance, the consumer healthcare sector is expanding rapidly, and more drugs are now available, thanks to the growing demand for weight-loss drugs.
  • A new regulatory framework has also been established to make Orlistat affordable and accessible to the population, making it a more affordable option for patients.

As the industry continues to grow, the Orlistat market is projected to grow at a compound annual growth rate of 6.8% annually, while its market share is expected to grow to 9.2% from 9.3% in the first quarter of 2014. And as the market continues to grow, the demand for Orlistat is expected to rise.

According to data from the World Health Organization (WHO), the global Orlistat market was estimated at USD 1.3 billion in 2015. This includes the global market for the brand-name drug Orlistat, which is available in 120 countries around the world. This market is expected to grow at a compound annual growth rate of 2.3% annually, which will allow the Orlistat market to become more competitive over the next few years.

The Orlistat market has been growing for the past five years, with the global number of pharmaceutical products increasing at a compound annual growth rate of 5.2% annually. The market for Orlistat is expected to grow at a compound annual growth rate of 1.2% annually, while the market share for the brand-name drug Orlistat will grow to 6% from 6% in the first quarter of 2014.

As of 2020, the Orlistat market had been estimated at USD 1.3 billion, and it was expected to grow at a compound annual growth rate of 2.4% annually. The market for Orlistat is expected to grow at a compound annual growth rate of 1.5% annually, while the market share for the brand-name drug Orlistat will grow to 6% from 6% in the first quarter of 2014.

The Orlistat market has been growing in the past five years, with the market for the brand-name drug Orlistat increasing at a compound annual growth rate of 1.8% annually, with its market share increasing at a compound annual growth rate of 1.9% annually, and it is expected to grow at a compound annual growth rate of 1.8% annually, while the market share for the brand-name drug Orlistat will grow at a compound annual growth rate of 1.9% annually, with its market share increasing at a compound annual growth rate of 1.9% annually. The growth in the Orlistat market will be due to the rising adoption of Orlistat by consumers worldwide.

The Orlistat market has been growing steadily and is expected to grow at a compound annual growth rate of 1.4% annually. The market for the brand-name drug Orlistat is projected to grow at a compound annual growth rate of 1.8% annually, with its market share increasing at a compound annual growth rate of 1.9% annually. The market for the brand-name drug Orlistat is expected to grow at a compound annual growth rate of 1.8% annually, with its market share increasing at a compound annual growth rate of 1.9%.